SS-31

SS-31 (Elamipretide) is a synthetic, cell-permeable tetrapeptide that specifically targets the inner mitochondrial membrane. It is characterized by its alternating aromatic and basic amino acids, which allow it to interact selectively with cardiolipin, a unique phospholipid essential for mitochondrial structure and function. Laboratory studies utilizing SS-31 focus on its ability to stabilize mitochondrial supercomplexes and reduce the production of reactive oxygen species (ROS). Researchers investigate its mechanisms of action in protecting cellular models against oxidative stress and restoring mitochondrial bioenergetics under various experimental conditions.